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Prof. LIU Dehua

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Professor and Director
Institute of Applied Chemistry
Department of Chemical Engineering
Tsinghua University, Beijing 100084, China
Phone and Fax: +86-10-62792128
Email: dhliu@tsinghua.edu.cn

 

 

 

 

Education

1986-1991

Ph.D., Chemical Engineering, Tsinghua University, Beijing, China

1981-1986

B.S.,  Applied Chemistry, Tsinghua University, Beijing, China

Appointments

2010-present

Director, Tsinghua-UFRJ China-Brazil Center for Climate Change and Energy Technology Innovation

1999-present

Professor and Director,  Institute of Applied Chemistry, Department of Chemical Engineering, Tsinghua University, Beijing, China

2014-present

Member, PlantBottle Technical Advisory Board (TAB) of Coca Cola

2008-2011

Consultant, DuPont

1997-1999

Professor, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China

1993-1997

Associate Professor, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China

1994-1995

Visiting Scholar, Laboratory of Renewable Resources Engineering, Purdue University, West Lafayette, IN, USA

1991-1993

Post-Doctoral Research Assistant, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, China

Research Field

Dr. Dehua Liu has expertise in the field of biochemical engineering with specific focus on renewable resources, bio-energy engineering, fermentation technology, bioreaction engineering, and metabolic engineering. He has published more than 200 papers and held 58 patents.

Selected Awards

  1. 2012, Advanced Individual in International Cooperation and Communication, Tsinghua University, Beijing, China
  2. 2011, Outstanding Invited Editor Awards, Chinese Journal of Biotechnology
  3. 2010, Exemplary Personal Achievement, China Petroleum and Chemical Industry Federation
  4. 2010, Exemplary Personal Achievement, Tsinghua University, Beijing, China
  5. 2007, Gold Bridge Award, China Marketing Association
  6. 2006, First Prize, Technology Advancement, China Petroleum and Chemical Industry Federation
  7. 2003, Outstanding Rookie Scholar of the Year, Tsinghua University, Beijing, China
  8. 2002, Exemplary Personal Achievement, Tsinghua University, Beijing, China

 

Selected Publications (2006-2014)

  1. Feng Qi, Yuki Kitahara, Zitian Wang, Xuebing Zhao, Wei Du, Dehua Liu. Novel mutant strains of Rhodosporidium toruloides by plasma mutagenesis approach and their tolerance for inhibitors in lignocellulosic hydrolyzate. Journal of Chemical Technology and Biotechnology, May 2014, 89: 735-742
  2. Yang Li, Wei Du, Dehua Liu. Exploration on the effect of phospholipids on free lipase-mediated biodiesel production. Journal of Molecular Catalysis B-Enzymatic Apr 2014, 102: 88-93
  3. Hyun Tae Hwang, Feng Qi, Chongli Yuan, Xuebing Zhao, Doraiswami Ramkrishna, Dehua Liu, Arvind Varma. Lipase-Catalyzed Process for Biodiesel Production: Protein Engineering and Lipase Production. Biotechnology and  Bioengineering, Apr 2014, 111: 639-653
  4. Xuebing Zhao, Yuichi Morikawa, Feng Qi, Jing Zeng, Dehua Liu. A novel kinetic model for polysaccharide dissolution during atmospheric acetic acid pretreatment of sugarcane bagasse. Bioresource Technology, Jan 2014, 151: 128-136
  5. Yang Li，Wei Du，Dehua Liu. Effect of phospholipids on free lipase-mediated methanolysis for biodiesel production[J]. Journal of Molecular Catalysis B: Enzymatic, 2013, 91: 67-71.
  6. Qiang Li，Jingyang Xu，Wei Du，Yang Li， Dehua Liu.Ethanol as the acyl acceptor for biodiesel production[J]. Renewable and Sustainable Energy Reviews, 2013, 25: 742-748.
  7. Ren H, Li Y, Du W, et al. Free lipase-catalyzed esterification of oleic acid for fatty acid ethyl ester preparation with response surface optimization[J]. Journal of the American Oil Chemists' Society, 2013, 90(1): 73-79.
  8. Jingyang Xu, Wei Du, Xuebing Zhao, Guoling Zhang and Dehua Liu. Microbial oil production from various carbon sources and its use for biodiesel preparation[J]. Biofuels, Bioproducts and Biorefining, 2013, 7(1): 65-77.
  9. Xuebing Zhao，Lei Dong，Liang Chen，Dehua Liu. Batch and multi-step fed-batch enzymatic saccharification of Formiline-pretreated sugarcane bagasse at high solid loadings for high sugar and ethanol titers[J]. Bioresource technology, 2013, 135: 350-356.
  10. Xuebing Zhao, Dehua Liu. Kinetic modeling and mechanisms of acid-catalyzed delignification of sugarcane bagasse by aqueous acetic acid[J]. BioEnergy Research, 2013, 6(2): 436-447.
  11. Lu He, Xuebing Zhao, Keke Cheng, Yan Sun, Dehua Liu. Kinetic modeling of fermentative production of 1, 3-propanediol by Klebsiella pneumoniae HR526 with consideration of multiple product inhibitions[J]. Applied biochemistry and biotechnology, 2013, 169(1): 312-326.
  12. Xuebing Zhao，Ming Fan，Jing Zeng，Wei Du，Canming Liu，Dehua Liu. Kinetics of lipase recovery from the aqueous phase of biodiesel production by macroporous resin adsorption and reuse of the adsorbed lipase for biodiesel preparation[J]. Enzyme and microbial technology, 2013, 52(4): 226-233.
  13. Qiang Li, Xuebing Zhao, Keke Cheng, Wei Du，Dehua Liu, Simulation and experimentation on the gas holdup characteristics of a novel oscillating airlift loop reactor[J]. Journal of Chemical Technology and Biotechnology, 2013, 88(4): 704-710.
  14. Zhao Xuebing, Zhang Lihua, Liu Dehua. Biomass recalcitrance. Part II: Fundamentals of different pre-treatments to increase the enzymatic digestibility of lignocelluloses. BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR, 6(5): 561-579, 2012
  15. Cheng Keke, Zhao Xuebing, Zeng Jing, Wu Ruchun, Xu Yunzhen, Liu Dehua, Zhang Jianan. Downstream processing of biotechnological produced succinic acid. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 95(4): 841-850, 2012
  16. Zhao Xuebing, Liu Dehua. Fractionating pretreatment of sugarcane bagasse by aqueous formic acid with direct recycle of spent liquor to increase cellulose digestibility-the Formiline process, BIORESOURCE TECHNOLOGY, 117: 25-32, AUG 2012
  17. Zhao Xuebing, Peng Feng, Du Wei, Liu Canming, Liu Dehua. Effects of some inhibitors on the growth and lipid accumulation of oleaginous yeast Rhodosporidium toruloides and preparation of biodiesel by enzymatic transesterification of the lipid, BIOPROCESS AND BIOSYSTEMS ENGINEERING, 35 (6): 993-1004, 2012
  18. Zhao Xuebing, Zhang Lihua, Liu Dehua. Biomass recalcitrance. Part I: the chemical compositions and physical structures affecting the enzymatic hydrolysis of lignocelluloses, BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR, 6(4): 465-482, 2012
  19. Xu Jingyang, Zhao Xuebing, Wang Wencong, Du Wei, Liu Dehua. Microbial conversion of biodiesel byproduct glycerol to triacylglycerols by oleaginous yeast Rhodosporidium toruloides and the individual effect of some impurities on lipid production, BIOCHEMICAL ENGINEERING JOURNAL, 65: 30-36, 2012
  20. Duan Zhangqun, Du Wei, Liu Dehua. Rational synthesis of 1,3-diolein by enzymatic esterification. JOURNAL OF BIOTECHNOLOGY, 159(1-2): 44-49, 2012
  21. Li Yang, Du Wei, Liu Dehua. Effect of Phospholipids on the Catalytic Performance of Lipase, CHINESE JOURNAL OF CATALYSIS, 33(3): 389-39, 2012
  22. Zhao Xuebing, Zhou Yujie, Liu Dehua. Kinetic model for glycan hydrolysis and formation of monosaccharides during dilute acid hydrolysis of sugarcane bagasse. BIORESOURCE TECHNOLOGY, 105: 160-168, 2012
  23. Ren Hongjie, Du Wei, Liangliang Lv, Liu Dehua. Study on Free Lipase-Catalyzed Ethanolysis for Biodiesel Preparation in an Oil/Water Biphasic System, Journal of the American Oil Chemists' Society, p 1-5, 2011
  24. Chen Zhen, Hongjuan Liu, Dehua Liu. Metabolic pathway analysis of 1,3-propanediol production with a genetically modified Klebsiella pneumoniae by overexpressing an endogenous NADPH-dependent alcohol dehydrogenase, Biochemical Engineering Journal, 54:151-157, 2011
  25. Xu Yunzhen, Wu Ruchun, Zheng Zongming, Liu Dehua. Influence of dhaT mutation of K. pneumoniae on 1,3-propanediol fermentation, World Journal of Microbiology and Biotechnology, 27: 1491-1497, 2011
  26. Sun Ting, Du Wei, Liu Dehua. Comparative study on stability of whole cells during biodiesel production in solvent-free system. Process Biochemistry, 46: 661-664, 2011
  27. Zhao Xuebing, Van Der Heide Evert, Zhang Ting, Liu Dehua. Single-stage pulping of sugarcane bagasse with peracetic acid, Journal of Wood Chemistry and Technology, 31: 1-25, 2011
  28. Zhao XB; Wu RC; Liu DH. Production of pulp, ethanol and lignin from sugarcane bagasse by alkali-peracetic acid delignification; BIOMASS & BIOENERGY, 35(7): 2874-2882, 2011
  29. Zhao XB, Song YQ, Liu DH. Enzymatic hydrolysis and simultaneous saccharification and fermentation of alkali/peracetic acid-pretreated sugarcane bagasse for ethanol and 2,3-butanediol production; ENZYME AND MICROBIAL TECHNOLOGY, 49 (4): 413-419, 2011
  30. Sun XY, Zhao XB, Du W, Liu DH. Kinetics of Formic Acid-autocatalyzed Preparation of Performic Acid in Aqueous Phase; CHINESE JOURNAL OF CHEMICAL ENGINEERING, 19 (6): 964-971, 2011
  31. Zhao XB, van der Heide E, Zhang T, Liu DH. Delignification of Sugarcane Bagasse With Alkali and Peracetic Acid and Characterization of The Pulp; BIORESOURCES, 5(3): 1565-1580, 2010
  32. Chen Z, Liu HJ, Zhang JA, Liu DH. Elementary Mode Analysis for the Rational Design of Efficient Succinate Conversion from Glycerol by Escherichia coli; JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY; 518743, 2010
  33. Duan ZQ, Du W, Liu DH. The pronounced effect of water activity on the positional selectivity of Novozym 435 during 1,3-diolein synthesis by esterification; CATALYSIS COMMUNICATIONS; 11(5): 356-358, 2010
  34. Zheng ZM, Xu YZ, Wang TP, Dong CQ, Yang YP, Liu DH. Ammonium and phosphate limitation in 1,3-propanediol production by Klebsiella pneumonia; BIOTECHNOLOGY LETTERS; 32(2): 289-294, 2010
  35. Zhao XB, Zhou YJ, Zheng GJ, Liu DH. Microwave Pretreatment of Substrates for Cellulase Production by Solid-State Fermentation; APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY; 160(5): 1557-1571, 2010
  36. Guo NN, Zheng ZM, Mai YL, Liu HJ, Liu DH. Consequences of cps mutation of Klebsiella pneumoniae on 1,3-propanediol fermentation; APPLIED MICROBIOLOGY AND BIOTECHNOLOGY; 86(2): 701-707, 2010
  37. Duan ZQ, Du W, Liu DH. The solvent influence on the positional selectivity of Novozym 435 during 1,3-diolein synthesis by esterification; BIORESOURCE TECHNOLOGY; 101(7): 2568-2571, 2010
  38. Sun T, Du W, Zeng J, Dai LM, Liu DH. Exploring the effects of oil inducer on whole cell-mediated methanolysis for biodiesel production; PROCESS BIOCHEMISTRY; 45(4): 514-518, 2010
  39. Lv D, Du W, Zhang GL, Liu DH. Mechanism study on NS81006-mediated methanolysis of triglyceride in oil/water biphasic system for biodiesel production; PROCESS BIOCHEMISTRY; 45(4): 446-450, 2010
  40. Li W, Du W, Li Q, Sun T, Liu DH. Study on acyl migration kinetics of partial glycerides: Dependence on temperature and water activity; JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATI; 63 (1-2): 17-22, 2010
  41. Zhao XB, Zhang LH, Liu DH. Pretreatment of Siam weed stem by several chemical methods for increasing the enzymatic digestibility; BIOTECHNOLOGY JOURNAL; 5(5): 493-504, 2010
  42. Wu RC, Ren HJ, Xu YZ, Liu DH. The final recover of salt from 1,3-propanadiol fermentation broth; SEPARATION AND PURIFICATION TECHNOLOGY; 73(2): 122-125, 2010
  43. Sun T, Du W, Liu DH, Dai LM. Improved catalytic performance of GA cross-linking treated Rhizopus oryzae IFO 4697 whole cell for biodiesel production; PROCESS BIOCHEMISTRY; 45 (7): 1192-1195, 2010
  44. Zheng ZM, Xu YZ, Wang TP, Dong CQ, Yang YP, Liu DH. Ammonium and phosphate limitation in 1,3-propanediol production by Klebsiella pneumonia; BIOTECHNOLOGY LETTERS; 32(9): 1349-1349, 2010
  45. Li W, Du W, Li Q, Li RW, Liu DH. Dependence on the properties of organic solvent: Study on acyl migration kinetics of partial glycerides; BIORESOURCE TECHNOLOGY; 10 (15): 5737-5742, 2010
  46. Chavez E, Liu DH, Zhao XB. Biofuels Production Development and Prospects in China; JOURNAL OF BIOBASED MATERIALS AND BIOENERGY; 4(3): 221-242, 2010
  47. Zhao XB, Liu DH. Chemical and thermal characteristics of lignins isolated from Siam weed stem by acetic acid and formic acid delignification; INDUSTRIAL CROPS AND PRODUCTS; 32(3): 284-291, 2010
  48. Liu HJ, Xu YZ, Zheng ZM, Liu DH. 1,3-Propanediol and its copolymers: Research, development and industrialization; BIOTECHNOLOGY JOURNAL; 5(11): 1137-1148, 2010
  49. Li W, Li RW, Li Q, Du W, Liu DH. Acyl migration and kinetics study of 1(3)-positional specific lipase of Rhizopus oryzae-catalyzed methanolysis of triglyceride for biodiesel production; PROCESS BIOCHEMISTRY, 45 (12): 1888-1893, 2010
  50. Duan ZQ, Du W, Liu DH. Novozym 435-catalyzed 1,3-diacylglycerol preparation via esterification in t-butanol system, PROCESS BIOCHEMISTRY, 45 (12): 1923-1927, 2010
  51. Sun T, Du W, Liu Dehua. Prospective and impacts of whole cell mediated alcoholysis of renewable oils for biodiesel production, BIOFUELS BIOPRODUCTS & BIOREFINING-BIOFPR. 3 (6):633-639, 2009  
  52. Xu YZ, Guo NN, Zheng ZM, Ou XJ, Liu HJ, Liu Dehua. Title Metabolism in 1,3-Propanediol Fed-Batch Fermentation by a D-Lactate Deficient Mutant of Klebsiella pneumonia, BIOTECHNOLOGY AND BIOENGINEERING 104 (5):965-972, 2009 
  53. Chen Z; Liu HJ; Zhang JA; Liu Dehua. Cell physiology and metabolic flux response of Klebsiella pneumoniae to aerobic conditions. PROCESS BIOCHEMISTRY. 44 (8):862-868, 2009
  54. Zheng ZM, Guo NN, Hao J, Cheng KK, Sun Y, Liu Dehua. Scale-up of micro-aerobic 1,3-propanediol production with Klebsiella pneumonia CGMCC 1.6366. PROCESS BIOCHEMISTRY 44 (8):944-948, 2009
  55. Chen Z, Liu HJ, Liu Dehua. Regulation of 3-hydroxypropionaldehyde accumulation in Klebsiella pneumoniae by overexpression of dhaT and dhaD genes. ENZYME AND MICROBIAL TECHNOLOGY 45 (4):305-309, 2009
  56. Hong AA, Cheng KK, Peng F, Zhou S, Sun Y, Liu CM, Liu Dehua. Strain isolation and optimization of process parameters for bioconversion of glycerol to lactic acid. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY 84 (10):1576-1581, 2009
  57. Duan ZQ, Du W, Liu Dehua. Enzymatic Approach for 1,3-Diacylglycerol Preparation. PROGRESS IN CHEMISTRY 21 (9):1939-1944, 2009
  58. Zhao Xuebing, Zhang Lihua, Liu Dehua. Comparative study on chemical pretreatment methods for improving enzymatic digestibility of crofton weed stem. BIORESORSE TECHNOLOGY. 99(9): 3729-3736, 2008
  59. Chen Zhen, Liu Hongjuan, Liu Dehua. Decrease the accumulation of 3-hydroxypropionaldehyde for 1,3-propanediol production by expressing the Yqhd gene in Klebsiella pneumonia. JOURNAL OF BIOTECHNOLOGY, 136(4), 2008
  60. Zheng Zongming, Cheng Keke, Hu Qiulong, Liu Hongjuan, Guo Nini,  Liu Dehua. Effect of culture conditions on 3-hydroxypropionaldehyde detoxification in 1,3-propanediol fermentation by Klebsiella pneumoniae. Biochemical Engineering Journal. 39(2):305-310, 2008
  61. Chen Xin, Du Wei, Liu Dehua. Effect of several factors on soluble lipase-mediated biodiesel preparation in the biphasic aqueous-oil systems WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY,  24(10):2097-2102, 2008
  62. Liu Dehua, Du Wei, Sun Hongjuan, Liu Yan. Integrated production for biodiesel and PDO with lipase-catalyzed transesterification and fermentation, JOURNAL OF BIOTECHNOLOGY, 136(S1): S287-S288, 2008
  63. Hao Jian, Lin Rihui, Zheng Zongming, Liu Hongjuan, Liu Dehua. Isolation and characterization of microorganisms able to produce 1,3-propanediol under aerobic conditions. WORLD JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY. 24(9):1731-1740, 2008
  64. Chen Xin, Du Wei, Liu Dehua, Ding Fuxin. Lipase-mediated methanolysis of soybean oils for biodiesel production. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 83(1):71-76, 2008
  65. Zhao Xuebing, Wang Lei, Liu Dehua. Peracetic acid pretreatment of sugarcane bagasse for enzymatic hydrolysis: A continued work JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 83(6):950-956, 2008
  66. Du Wei, Li Wei, Sun Ting, Chen Xin, Liu Dehua. Perspectives for biotechnological production of biodiesel and impacts. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 79(3):331-337, 2008
  67. Li Qiang, Du Wei, Liu Dehua. Perspectives of microbial oils for biodiesel production. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2008, 80(5):749-756, 2008
  68. Zheng Zongming, Xu Yunzhen, Liu Hongjuan, Guo Nini, Cai Zhongzhen, Liu Dehua.  Physiologic mechanisms of sequential products synthesis in 1,3-propanediol fed-batch fermentation by Klebsiella pneumoniae. Biotechnology and Bioengineering, 100(5):923-932, 2008
  69. Zhao Xuebing, Cheng Keke, Hao Junbin, Liu Dehua. Preparation of peracetic acid from hydrogen peroxide, part II: Kinetics for spontaneous decomposition of peracetic acid in the liquid phase. JOURNAL OF MOLECULAR CATALYSIS: CHEMICAL. 284:58-68, 2008
  70. Chen Xin, Du Wei, Liu Dehua. Response surface optimization of biocatalytic biodiesel production with acid oil. BIOCHEMICAL ENGINEERING JOURNAL. 40(3):423-429, 2008
  71. Li Wei, Du Wei, Liu Dehua. Rhizopus oryzae whole-cell-catalyzed biodiesel production from oleic acid in terf-butanol medium. ENERGY AND FUELS. 22(1):155-158, 2008
  72. Zheng Zongming, Hu Qiulong, Hao Jian, Xu Feng, Guo Nini, Sun Yan, Liu Dehua. Statistical optimization of culture conditions for 1,3-propanediol by Klebsiella pneumoniae AC01 via central composite design. BIORESORCE TECHNOLOGY. 99(5):1052-1056, 2008
  73. Li Wei, Du Wei, Liu Dehua, Yao Yuan. Study on factors influencing stability of whole cell during biodiesel production in solvent-free and tert-butanol system. BIOCHEMICAL ENGINEERING JOURNAL. 41(2):111-115, 2008
  74. Xu Yongxiang, Xu Jun, Liu Dehua, Guo Baohua, Xie Xuming. Synthesis and characterization of biodegradable poly(butylene succinate-co-propylene succinate). JOURNAL OF APPLIED POLYMER SCIENCE. 109(3):1881-1889, 2008
  75. Du W; Wang L; Liu DH. Improved methanol tolerance during Novozym435-mediated methanolysis of SODD for biodiesel production. GREEN CHEMISTRY, 9(2): 173-176, 2007
  76. Li W; Du W; Liu DH. Optimization of whole cell-catalyzed methanolysis of soybean oil for biodiesel production using response surface methodology. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 45 (3-4): 122-127, 2007
  77. Du W, Xu YY, Liu DH. Lipase-catalyzed transesterification of soya bean oil for biodiesel production during continuous batch operation. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, 38: 103-106, Part 2, 2003
  78. Li LL, Du W, Liu DH, Wang L, Li ZB. Lipase-catalyzed transesterification of rapeseed oils for biodiesel production with a novel organic solvent as the reaction medium. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 43 (1-4): 58-62, 2006
  79. Xu YX, Xu J, Sun YB, Liu DH, Guo BH, Xie XM. Crystallization behavior of poly( butylene succinate-co-propylene succinate)s. ACTA POLYMERICA SINICA, (8): 1000-1006, 2006
  80. Zeng J, Du W, Liu XY, Liu DH, Dai LM. Study on the effect of cultivation parameters and pretreatment on Rhizopus oryzae cell-catalyzed transesterification of vegetable oils for biodiesel production. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 43 (1-4): 15-18, 2006
  81. Wang L, Du W, Liu DH, Li LL, Dai NM. Lipase-catalyzed biodiesel production from soybean oil deodorizer distillate with absorbent present in tert-butanol system. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 43 (1-4): 29-32, 2006


Professional Affiliations

  1. Chairman, 1st-7th World Bioenergy Symposium (WBS), 2001-2013. WBS won good reputation since being initiated
  2. Editorial Board, Biofuels, UK
  3. Editorial Board, International Journal of Industrial Biotechnology, India
  4. Editorial Board, Chinese Journal of Biotechnology, China
  5. Editorial Board, Chinese Journal of Process Engineering, China
  6. Editorial Board, Journal of Chemical Engineering of Chinese Universities, China
  7. Editorial Board, Biotechnology & Business, China

 

Selected Patents

  1. An Airlift Loop Reactor with low height to diameter ratio and concentric multiple draft tube; Liu Dehua, Xu Yuanyuan, Xie Dongming, Chen Hongshu; Patent Number: 02129483.6; Granted Date: 2004.10.20.
  2. A method to produce biodiesel; Du Wei, Xu Yuanyuan, Liu Dehua; Patent Number: 03119600.4; Granted Date: 2004.12.22; PCT Application Number: P2003293C.
  3. A method of biodiesel production using lipid; Liu Dehua, Du Wei, Xu Yuanyuan, Chen Jian; Patent Number: 03150231.8; Grant Date: 2005.2.13.
  4. Electrodialysis Application in the Desalting process of Fermentation Broth of 1,3-Propanediol, Wang Xiaolin, Gong Yan, Tang Yu, Liu Dehua; Patent Number: 03104871.4; Granted Date: 2005.3.2.
  5. New Technology of Biodiesel Production from Oils by Lipase Conversion in the organic medium reaction system; Du Wei, Xu Yuanyuan, Liu Dehua, Chen Jian, Zeng Jing, Li Lilin; Patent Number: 200410000697.9; Granted Date: 2006.1.25; PCT Application Number: P2004351C.
  6. Biodiesel Production with Combined Lipase as Catalyst; Liu Dehua, Du Wei, Li Lilin, Wang Li, Li Zebo; Patent Number: 200510011623.X; Granted Date: 2006.11.1.
  7. 1,3-Propanediol and 2,3-Butanediol Production from Glycerol by Two Stage Fermentation; Liu Dehua, Sun Yan; Cheng Keke, Liu Weibin, Liu Hongjuan; Patent Number: 200410037692.3; Granted Date: 2006.3.22.
  8. New Reaction Extraction Process of Lower Polyhydric Alcohols from Dilute Aqueous Solution; Liu Dehua, Hao Jian, Xiang Botao, Chen Shufeng; Patent Number: 200410038300.5; Granted Date: 2006.3.22.
  9. Lipid Extraction from Oil Feedstock directly using Chain Fatty Acid Esters as solvent; Liu Dehua, Li Lilin, Du Wei, Xu Yuanyuan; Patent Number: 200410038298.1; Granted Date: 2006.6.7.
  10. An Airlift Loop Reactor without outside gases; Patent Number: 2007.11.7; Granted Date: NP200700368.
  11. Biodiesel Production from Fatty Acids and Oils which Contain Fatty Acids with Microbial cells as catalyst; Du Wei, Liu Dehua, Li Wei; Patent Number: 200610089767.1; Granted Date: 2007.11.7.
  12. A Pretreatment Method of Filtration of Pairs of Capsular Bacterium Fermentation Broth; Liu Dehua, Hao Jian, Wei Mingquan, Qiao Jianyuan, Du Fengguang, Qiao Kai; Patent Number: 200610011694.4; Granted Date: 2007.12.19.
  13. Method for Biodiesel Production from Oils which Contain Fatty Acids by Two Step Catalysis; Liu Dehua, Li Lilin, Li Qiang, Du Wei; Patent Number: 200610057164.3; Granted Date: 2007.12.9.
  14. Method for Cellulase Production by Integrated Semi-continuous Solid State Fermentation and Extraction; Zhou Yujie, Chen Shufeng, Zhang Jianan, Liu Dehua; Patent Number: 200510002222.8; Granted Date: 2007.2.7
  15. Method for Cellulase Production by Solid State Fermentation with Electric Field Enhancement; Liu Dehua, Zhou Yujie, Liu Zheng, Yuan Naiju, Zhang Jianan, Zhao Xuebing; Patent Number: 200510002223.2; Granted Date: 2007.2.7.
  16. Method for High Purity Methyl Acetate Production directly from Methyl Acetate Waste Liquid or Gas; Chen Jian, Liu Dehua, Zhang Ting, Du Wei; Patent Number: 200510002905.3; Granted Date: 2007.2.7
  17. Method for Separation of 1, 3-Propanediol and By-products from Fermentation Broth; Patent Number: 200410083940.8; Granted Date: 2007.3.14.
  18. Method for High Purity Methyl Acetate Production with Liquid Phase Adsorption Process; Patent Number: 200510011610.2; Granted Date: 2007.3.14.
  19. Method for 1,3-Propanediol Production promoted by Fermentation with an Exogenous Fumaric Acid; Liu Dehua, Lin Rihui, Liu Hongjuan; Patent Number: 200510011917.2; Granted Date: 2007.3.14.
  20. Method for 1,3-Propanediol Production from the Glycerol, By-product of Biodiesel; Liu Dehua, Liu Hongjuan, Lin Rihui, Hao Jian; Patent Number: 200510011867.8; Granted Date: 2007.7.18; PCT Application Number: NP200700369.
  21. New Technology of Vitamin E and Sterol Extraction from Plant Oil Deodorizer Distillate; Liu Dehua, Du Wei, Xu Yuanyuan, Sun Dengwen; Patent Number: 200410008678.0; Granted Date: 2007.8.22.
  22. Method for 1,3-Propanediol and 2,3-Butanediol Production from Crude Starch Feedstock, Liu Dehua, Cheng Keke, Liu Hongjuan, Lin Rihui, Hao Jian; Patent Number: 200510011959.6; Granted Date: 2008.10.22; PCT Application Number: Z0712700CPEP.
  23. Method for Biodiesel Production Catalyzed by Microbial Cells in the Organic Medium Reaction System; Du Wei, Liu Dehua, Li Wei; Patent Number: 200610089644.8; Granted Date: 2008.7.23.
  24. Method for 1,3-Propanediol Production by Microbial Aerobic Fermentation; Patent Number: 200510086677.2; Granted Date: 2009.5.27.
  25. Extraction Process for 1,3-Propanediol Production by Fermentation Process, Patent Number: 200710065558.8; Granted Date: 2009.3.18.
  26. Process for Biodiesel Production Catalyzed by 1,3-Position Specific lipase from Oils which Contain Fatty Acids; Patent Number: 200710065212.8; Granted Date: 2009.10.21.
  27. Method for Enzyme-mediated 1,3- diacylglycerol Production in the Petroleum Ether Medium System; Du Wei, Liu Dehua, Duan Zhangqun; Patent Number: 200810105082.0; Granted Date: 2011.05.11.
  28. Process for Enzyme-mediated Biodiesel Production with Online Membrane dehydration; Patent Number: 200810117843.4; Granted Date: 2011.8.26.
  29. Process for Biodiesel Production Catalyzed by Recovered Non-immobilization Lipase; De Wei, Liu Dehua, Lv Dan; Patent Number: 200810224315.9; Granted Date: 2011.11.30.
  30. Process for Enzyme-mediated 1,3- diacylglycerol Production in the tertiary butanol Medium; Du Wei, Liu Dehua, Duan Zhangqun; Patent Number: 200810112255.1; Granted Date: 2008.05.22.
  31. Technology for High Yield Production of 1,3-Propanediol by Fermentation; Liu Dehua, Sun Yan, Liu Hongjuan, Lin Rihui, Hao Jian; Patent Number: 200710063347.0; Granted Date: 2007.01.09.
  32. Method for Biodiesel Production from Renewable Oils with Membrane-Recycled Lipase as Catalyst; Patent Number: 200810239182.2; Granted Date: 2008.12.11.
  33. Method for Microbial Flocculent Production from By-product Bacterial of Fermentation; Sun Yan, Liu Dehua, Liu Zhongming; Patent Number: 200810103128.5; Granted Date: 2010.4.7.
  34. Method for Integrated Production of PDO, BDO and PHP with Gene Engineering Bacteria; Liu Dehua, Liu Hongjuan, Ou Xianjin, Sun Yan, Xu Yunzhen, Lei Yueyong, Liu Weibin; Patent Number: 200810105722.8; Granted Date: 2011.8.17.
  35. Method for Construction of capsular missing Klebsiella, Liu Dehua, Liu Hongjuan, Guo Nini, Ou Xianjin, Fang Jianjun, Luo Jian; Patent Number: 200810117844.9; Granted Date: 2010.12.15.
  36. Method for Biorefinery of Lignocellulose; Patent Number: 200910084431.X; Granted Date: 2011.3.30.


Selected Current and Past Support (2005-2013)


Current Support
  1. Project Title: Enzymatic Biodiesel Pilot Plant Demonstration in Brazil
    Project Period: 2013-2015
    Funding Agency: Ministry of Science and Technology of Brazil
    Award Amount: 3,100,000 R$
    Role: PI
    Co-PI: Jose Pinguelli
  2. Project Title: Demonstration of Conversion Technology for Integration of Electricity and Ethanol from lignocellulosic Biomass
    Project Period: 2013-2015
    Funding Agency: China National Energy Administration
    Award Amount: 2,300,000 RMB
    Role: PI
  3. Project Title: Implementation of China-Brazil Center for Climate Change and Energy Technology Innovation
    Project Period: 2013-2014
    Funding Agency: Ministry of Science and Technology of China
    Award Amount: 1,700,000 RMB
    Role: PI
  4. Project Title: Microbial Lipid Production from Low-cost Carbon Sources and Key Technology and Mechanism of Enzymatic Conversion of Lipids to Biodiesel
    Project Period: 2012-2014
    Funding Agency: Independent Research Fund of Tsinghua University
    Award Amount: 800,000 RMB
    Role: PI
  5. Project Title: China-Brazil Center for Climate Change and Energy Technology Innovation
    Project Period: 2010-2014
    Funding Agency: Ministry of Science and Technology of Brazil
    Award Amount: 240,000 USD
    Role: PI
  6. Project Title: New Technology of 1,3-Propanediol Production by Fermentation
    Project Period: 2010-2014
    Funding Agency: Jiangsu Shenghong Group, China
    Award Amount: 3,100,000 RMB
    Role: PI

Past Support

  1. Project Title: Key Technology Development and Industrial Demonstration of Liquid Biofuel
    Project Period: 2010-2013
    Funding Agency: Ministry of Science and Technology of China
    Award Amount: 5,540,000 RMB
    Role: PI
  2. Project Title: Biorefinery Technology of 1,3-Propanediol
    Project Period: 2006-2010
    Funding Agency: 863 Project, Ministry of Science and Technology of China
    Award Amount: 8,400,000 RMB
    Role: PI
  3. Project Title: Development and Application of Key Technologies of Recycling Resources in Ethanol Industrial Park
    Project Period: 2006-2010
    Funding Agency: Key Projects in the National Science & Technology Pillar Program during 11th Five Year Plan, Ministry of Science and Technology of China
    Award Amount: 500,000 RMB
    Role: PI
  4. Project Title: Study on Mass Transfer and Metabolism Regulation in Coupled Solid State Fermentation
    Project Period: 2004-2008
    Funding Agency: 973 Project, Ministry of Science and Technology of China
    Award Amount: 500,000 RMB
    Role: PI
  5. Project Title: Stability of Enzyme during Biodiesel Production
    Project Period: 2006-2009
    Funding Agency: International Science and Technology Cooperation Project, Ministry of Science and Technology of China
    Award Amount: 900,000 RMB
    Role: PI
  6. Project Title: Study on key technologies of enzyme-mediated biodiesel industrialization
    Project Period: 2006-2008
    Funding Agency: Research Foundation from Ministry of Education of China
    Award Amount: 500,000 RMB
    Role: PI
  7. Project Title: Research on Metabolism Mechanism of Microbial Lipid Accumulation and its Enzymatic Conversion to Biodiesel
    Project Period: 2010-2011
    Funding Agency: Independent Research Fund of Tsinghua University
    Award Amount: 980,000 RMB
    Role: PI
  8. Project Title: Biodiesel Production from Renewable Oils with Enzyme approaches
    Project Period: 2006-2011
    Funding Agency: Hunan Rivers Bioengineering Co. Ltd., China
    Award Amount: 14,600,000 RMB
    Role: PI
  9. Project Title: New Technology of 1,3-Propanediol Production by Fermentation
    Project Period: 2009-2012
    Funding Agency: Tianguan Group, China
    Award Amount: 3,350,000 RMB
    Role: PI
  10. Project Title: New Technology of 1,3-Propanediol Production by Fermentation
    Project Period: 2009-2012
    Funding Agency: Heilongjiang Chenneng Bioengineering Co. Ltd., China
    Award Amount: 1,350,000 RMB
    Role: PI
  11. Project Title: BioEthanol for Sustainable Transport
    Project Period: 2006-2010
    Funding Agency: European Sixth Framework Program
    Award Amount: 370,000 EUR
    Role: PI and Chinese coordinator
  12. Project Title: Development of strains and processes for cellulose and ethanol production
    Project Period: 2008-2010
    Funding Agency: M&G, Italy
    Award Amount: 140,000 EUR
    Role: PI
  13. Project Title: Organosolv pulping of biomass
    Project Period: 2005-2009
    Funding Agency: Shell
    Award Amount: 70,000 USD
    Role: PI
  14. Project Title: Bioconversion of Palm Lignocellulose to Bioethanol
    Project Period: 2011-2012
    Funding Agency: MPOB, Malaysia
    Award Amount: 1,600,000 RMB
    Role: PI


Current and Past Ph.D. Students

Current Ph.D. Students: Li Yang, Tang Ting, Chen Hongmei, Cui Xinkai

Current Post-doctoral Research Assistant: Qi Feng

Past Ph.D. Students:

  1. Xie Dongming, PI, DuPont, USA 
  2. Xu Yuanyuan, Patent Examination Cooperation Center of the Patent Office, SIPO, Beijing, China
  3. Cheng Keke, Assistant Professor, Tsinghua University, Beijing, China
  4. Zhang Ting, Technical Analyst, GM, Beijing, China
  5. Lin Rihui, Associate Professor, Guangxi University for Nationalities, Nanning, China
  6. Hao Jian, Associate Professor, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, China
  7. Zhao Xuebing, Assistant Professor, Tsinghua University, Beijing, China
  8. Li Wei, Novozymes, Beijing, China
  9. Zheng Zongming, Associate Professor, North China Electric Power University, Beijing, China
  10.  Chen Xin, ChemChina, Beijing, China
  11.  Guo Nini, Sinolink Securities, Shanghai, China
  12.  Sun Ting, Novozymes, Beijing, China
  13.  Xu Yunzhen, COFCO, Beijing, China
  14.  Li Qiang, State Grid Xinyuan Company LTD., Beijing, China
  15.  Sun Xiaoying, Institute of petroleum, General Logistics Department, Beijing, China
  16.  Duan Zhangqun, Associate Professor, Academy of State Administration of Grain, Beijing, China
  17.  Wu Ruchun, Professor, Guangxi University for Nationalities, Nanning, China
  18. Song Yuanquan, Schlumberger, Drilling & Measurements, in Labuan, Malaysia
  19. Xu Jingyang, Zhejiang Police College, Hangzhou, China   

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